Marijuana Compounds-Cannabinoids, Terpenes and Flavonoids Interaction Study Released


As more states migrate to the legalization of marijuana and the acceptance of Medical Marijuana in most states more research and studies are now being released around the cannabis and its components.

A new study with details just released says that only by examining such nuanced interactions between the various chemical compounds in marijuana to include cannabinoids, terpenes and flavonoids can the medical community and science better understanding of the components’ combined effects “is crucial for unravelling cannabis’s complete therapeutic potential.”

The recently released study provides a better picture of the complex web of chemical interactions that might influence marijuana’s effects on a person, but authors emphasized that “elucidating the synergistic effects and underlying mechanisms of cannabinoids, terpenes, and flavonoids demands a focused investigation.

The results were compiled in a research document titled The Neurotherapeutic Arsenal in Cannabis sativa: Insights into Anti-Neuroinflammatory and Neuroprotective Activity and Potential Entourage Effect by Ahmad K. Al-Khazaleh ,Xian ZhouDeep Jyoti Bhuyan Gerald W. MünchElaf Adel Al-Dalabeeh ,Kayla Jaye and Dennis Chang

The research looks at data compiled from NICM Health Research Institute, Western Sydney University, Penrith, NSW 2751, Australia, School of Science, Western Sydney University, Penrith, NSW 2751, Australia, Pharmacology Unit, School of Medicine, Western Sydney University, Penrith, NSW 2751, Australia and Department of Biological Sciences, School of Science, University of Jordan, Amman 11942, Jordan to drive its conclusions.

Per the research document; "Cannabis, renowned for its historical medicinal use, harbours various bioactive compounds—cannabinoids, terpenes, and flavonoids. While major cannabinoids like delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) have received extensive scrutiny for their pharmacological properties, emerging evidence underscores the collaborative interactions among these constituents, suggesting a collective therapeutic potential.

This comprehensive review explores the intricate relationships and synergies between cannabinoids, terpenes, and flavonoids in cannabis. Cannabinoids, pivotal in cannabis’s bioactivity, exhibit well-documented analgesic, anti-inflammatory, and neuroprotective effects.

Terpenes, aromatic compounds imbuing distinct flavours, not only contribute to cannabis’s sensory profile but also modulate cannabinoid effects through diverse molecular mechanisms. Flavonoids, another cannabis component, demonstrate anti-inflammatory, antioxidant, and neuroprotective properties, particularly relevant to neuroinflammation.

The entourage hypothesis posits that combined cannabinoid, terpene, and flavonoid action yields synergistic or additive effects, surpassing individual compound efficacy.

Recognizing the nuanced interactions is crucial for unravelling cannabis’s complete therapeutic potential.

Tailoring treatments based on the holistic composition of cannabis strains allows optimization of therapeutic outcomes while minimizing potential side effects. This review underscores the imperative to delve into the intricate roles of each.

Exploring these compounds’ biosynthesis, bioactivities, and biotechnological applications is pivotal for harnessing their therapeutic potential and diversifying treatment options,” they added, identifying a number of apparent gaps in research that warrant further study.

At the same time, the paper acknowledges that research into the federally controlled substance remains a major challenge.

Addressing regulatory barriers obstructing cannabis research is imperative,” it says. “Overcoming these obstacles, stemming from the classification of cannabis as a Schedule I substance, is crucial to expanding access to cannabis products for research purposes. Furthermore, this would enable a more comprehensive exploration of the therapeutic and adverse effects of cannabis and cannabinoids, fostering informed decision making in public health initiatives.”

“A comprehensive exploration of the synergies between cannabinoids, terpenes, and flavonoids, coupled with advancements in phytochemical research and the removal of regulatory barriers, holds the key to unlocking the full therapeutic potential of cannabis.”

While a recent review by the Department of Health and Human Services concluded that marijuana should be moved to Schedule III of the Controlled Substances Act, the department initially kept its reasoning secret, waiting months before publicly releasing a justification for the proposal as reported by on Newsbreak.

As legalization takes hold more research papers are being released and information can be found on our news feed.

Source: Sci Fi Profiles,

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